Field of study: Nanotechnologies
Level: Bachelor
Objectives: The aim of this course is to present how a natural biopolymer, can be used as a nanometric scaffold for the production of tunable structures. The DNA-based chemistry developped for more than 30 years brings a large panel of potentiel applications by grafting DNA strands on surfaces, nanoparticles, or proteins for instance. I propose an overview of the recent work illustrating the huge potential of DNA-based nanostructure for different applications.
I. DNA molecular structure and properties
- DNA and RNA chemical structures
- Biological functions of nucleic acids
- DNA (un)stability
- DNA synthesis (chemical and PCR-based)
II. Design of new functionalities for DNA
- Aptamers
- Data storage with DNA
III. DNA as a nanometric tunable object
- Seeman’s work
- DNA origamis, structures & design
- DNA based origamis for sensing
- DNA bricks
- DNA machines
- DNA multi-enzyme catalysts
IV. Some work completed in Grenoble
- DNA based nano-electronics
Lecture/contact hours: 3 hours
Teaching language: English
Detailed examination modalities: written exam
Instructor: Dr. Yoann Roupioz
Department: Université Grenoble Alpes, Commissariat à l'énergie atomique et aux énergies alternatives (CEA) et Centre national de la recherche scientifique (CNRS).
e-mail: yoann.roupioz@cea.fr
Level: Bachelor
Objectives: The aim of this course is to present how a natural biopolymer, can be used as a nanometric scaffold for the production of tunable structures. The DNA-based chemistry developped for more than 30 years brings a large panel of potentiel applications by grafting DNA strands on surfaces, nanoparticles, or proteins for instance. I propose an overview of the recent work illustrating the huge potential of DNA-based nanostructure for different applications.
I. DNA molecular structure and properties
- DNA and RNA chemical structures
- Biological functions of nucleic acids
- DNA (un)stability
- DNA synthesis (chemical and PCR-based)
II. Design of new functionalities for DNA
- Aptamers
- Data storage with DNA
III. DNA as a nanometric tunable object
- Seeman’s work
- DNA origamis, structures & design
- DNA based origamis for sensing
- DNA bricks
- DNA machines
- DNA multi-enzyme catalysts
IV. Some work completed in Grenoble
- DNA based nano-electronics
Lecture/contact hours: 3 hours
Teaching language: English
Detailed examination modalities: written exam
Instructor: Dr. Yoann Roupioz
Department: Université Grenoble Alpes, Commissariat à l'énergie atomique et aux énergies alternatives (CEA) et Centre national de la recherche scientifique (CNRS).
e-mail: yoann.roupioz@cea.fr